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Interleukin-6 (IL-6) is a crucial cytokine involved in immune regulation, inflammation, and disease progression. Concentrations of IL-6 are elevated in patients with infection, sepsis, and septicemia. IL-6 has a wide range of uses across a number of diseases and can be used to diagnose sepsis in adults and neonates, monitor infection after surgery, and is positively correlated with the severity of COVID-19.