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Gold Conjugates

Trusted Gold Conjugates from BBI

All of our conjugates are manufactured using our unique gold nanoparticles. We use our long-established proven processes to manufacture conjugates with outstanding performance and long-term stability. Our catalogue gold conjugates offer optimal performance, cost effectiveness and guaranteed quality, and are designed to help you develop and manufacture your assay rapidly and efficiently.

We manufacture all of our conjugates under our ISO13485 certification at our Crumlin headquarters.

BBI Solutions gold conjugates for lateral flow

Our catalogue range includes the following conjugates:

Anti-Biotin	Anti-Human	Control line	Anti-species	Fertility
Monoclonal anti Biotin 40nm	Goat anti Human IgG (H+L) 40nm	Chicken IgY 40nm	Goat anti Rabbit 40nm	Human Chorionic Gonadotropin (HCG) 40nm
Goat anti Biotin 40nm	Goat anti Human IgG 40nm	Mouse IgG 40nm	Goat anti Mouse IgG (H+L) 40nm	Human Luteinizing Hormone (LH) 40nm
	Goat anti Human IgM 40nm	Bovine Serum Albumin 40nm *
	Goat anti Human IgA 40nm	Goat anti Mouse IgG (H+L) 40nm
	Protein A 40nm	Goat anti Rabbit 40nm

*Negative control conjugate

Pease note: If you are based outside of the EU there will be a 5 day lead time added to your order to enable us to comply with the Animal and Plant Health Agency (APHA) export/import policy.

All of our conjugates are supplied at OD10 and are available as a 5ml sample, 100ml and 500ml pack sizes
If you are looking for a conjugate which is not in our standard product range, or for an existing conjugate to be supplied at a different OD, learn more about our custom conjugation service here or contact us with your requirements.

BBI Solutions Anti-Molecular Tag conjugates Particle size 40nm

	Product code	Particle size (nm)	OD	Pack size (ml)
Anti-Biotin conjugates	BA.MAB40/X BA.MAB40/7 BA.MAB40/8	40	10	5ml 100ml 500ml
Anti-Digoxin conjugates	BA.DIG40/x BA.DIG40/7 BA.DIG40/8	40	10	5ml 100ml 500ml
Anti-FITC conjugates	BA.FITC40/x BA.FITC40/7 BA.FITC40/8	40	10	5ml 100ml 500ml
Anti-His-Tag conjugates	BA.HT40/x BA.HT40/7 BA.HT40/8	40	10	5ml 100ml 500ml
Anti-HRP conjugates	BA.HRP40/x BA.HRP40/7 BA.HRP40/8	40	10	5ml 100ml 500ml

(Please contact us for availabiltiy of 500ml package sizes.)

BBI Solutions Gold Conjugates for Microscopy

Gold labels offer an effective method of labelling antigens for visualisation in the electron microscope.

BBI has a range of EM grade conjugates that combine different antibodies on a range of particles, predominantly from 5, 10 and 15nm. For researchers beginning to work with immunogold labelling, we recommend 10nm gold conjugates for observation, at a range of magnifications.

The main advantages of gold labelling lie in the high contrast and unequivocal nature of the label, the range of particle sizes suitable for different magnifications, the extreme sensitivity and the stability of the signal.

Please contact our Customer Services Team directly to discuss your requirements on tel:+44 (0) 1495 363000 or alternatively you can submit an enquiry here.

Secondary antibodies - Gold conjugated (EM grade)

Product description	Product code	Package size (ml)	Particle size (nm)	Immunoglobulin detected
Rabbit anti-Goat IgG: 10nm -0.25ml	EM.RAG10/1	0.25	10	Anti-Goat IgG
Rabbit anti-Goat IgG: 15nm -0.25	EM.RAG15/1	0.25	15
Rabbit anti-Goat IgG: 10nm -01ml	EM.RAG10/2	1	10
Rabbit anti-Goat IgG: 15nm -1ml	EM.RAG15/2	1	15
Goat anti-Guinea-pig IgG: 10nm -0.25ml	EM.GAG10/1	0.25	10	Anti-Guinea Pig IgG
Goat anti-Guinea-pig IgG: 10nm -1ml	EM.GAG10/2	1	10	Anti-Guinea Pig IgG
Goat anti-Human IgG: 10nm -0.25ml	EM.GAH10/1	0.25	10	Anti-Human IgG
Goat anti-Human IgG: 20nm -0.25ml	EM.GAH20/1	0.25	20
Goat anti-Human IgG: 10nm -1ml	EM.GAH10/2	1	10
Goat anti-Human IgG: 20nm -1ml	EM.GAH20/2	1	20
Goat anti-Mouse IgG: 10nm -0.25ml	EM.GAM10/1	0.25	10	Anti-Mouse IgG
Goat anti-Mouse IgG(H+L): 10nm -0.25ml	EM.GMHL10/1	0.25	20
Goat anti-Mouse IgG (H+L): 20nm -0.25ml	EM.GMHL20/1	0.25	10
Goat anti-Mouse IgG: 10nm -1ml	EM.GAM10/2	1	10
Goat anti-Mouse IgG(H+L): 10nm -1ml	EM.GMHL10/2	1	20
Goat anti-Mouse IgG(H+L): 20nm -1ml	EM.GMHL20/2	1	40
Goat anti-Mouse IgG+IgM: 10nm - 0.25ml	EM.GAF10/1	0.25	10	Anti-Mouse IgG + IgM
Goat anti-Mouse IgG+IgM: 10nm - 1ml	EM.GAF10/2	1	40	Anti-Mouse IgG + IgM
Goat anti-Rabbit IgG: 10nm -0.25ml	EM.GAR10/1	0.25	10	Anti-Rabbit IgG
Goat anti-Rabbit IgG: 15nm - 0.25ml	EM.GAR15/1	0.25	15
Goat anti-Rabbit IgG: 20nm - 0.25ml	EM.GAR20/1	0.25	20
Goat anti-Rabbit IgG: 40nm - 0.25ml	EM.GAR40/1	0.25	40
Goat anti-Rabbit IgG: 5nm - 0.25ml	EM.GAR5/1	0.25	5
Goat anti-Rabbit IgG: 10nm -1ml	EM.GAR10/2	1	10
Goat anti-Rabbit IgG: 15nm -1ml	EM.GAR15/2	1	15
Goat anti-Rabbit IgG: 20nm - 1ml	EM.GAR20/2	1	20
Goat anti-Rabbit IgG: 40nm - 1ml	EM.GAR40/2	1	40
Goat anti-Rabbit IgG: 5nm - 1ml	EM.GAR5/2	1	5
Goat anti-Rat IgG: 10nm - 0.25ml	EM.GAT10/1	0.25	10	Anti-Rat IgG
Goat anti-Rat IgG: 10nm - 1ml	EM.GAT10/2	1	10	Anti-Rat IgG

Secondary antibodies -Gold conjugated - Particle size 40nm

Product description	Product code	Package size (ml)	Immunoglobulin detected
Goat Anti Human IgA 40nm OD10 5ml	BA.GAHA40/X	5	Anti-human IgA
Goat Anti Human IgA 40nm OD10 100ml	BA.GAHA40/7	100
Goat Anti Human IgA 40nm OD10 500ml	BA.GAHA40/8	500
Anti-human IgE 40nm OD10 5mL	BA.MAHE40/x	5	Anti-human IgE
Anti-human IgE 40nm OD10 100mL	BA.MAHE40/7	100
Anti-human IgE 40nm OD10 500mL	BA.MAHE40/8	500
Goat Anti Human IgG (H+L) 40nm OD10 5ml	BA.GAHL40/X	5	Anti-human IgG
Goat Anti Human IgG 40nm OD10 5ml	BA.GAH40/X	5
Goat Anti Human IgG (H+L) 40nm OD10 100ml	BA.GAHL40/7	100
Goat Anti Human IgG 40nm OD10 100ml	BA.GAH40/7	100
Goat Anti Human IgG (H+L) 40nm OD10 500ml	BA.GAHL40/8	500
Goat Anti Human IgG 40nm OD10 500ml	BA.GAH40/8	500
Goat Anti Human IgM 40nm OD 10 5ml	BA.GAHM40/X	5	Anti-human IgM
Goat Anti Human IgM 40nm OD 10 100ml	BA.GAHM40/7	100
Goat Anti Human IgM 40nm OD 10 500ml	BA.GAHM40/8	500
Goat Anti Mouse IgG 40nm OD10 5ml	BA.GAM40/X	5	Anti-mouse IgG
Goat Anti Mouse IgG (H+L): 40nm OD10 5ml	CC.GAM40/X	5
Goat Anti Mouse IgG 40nm OD10 100ml	BA.GAM40/7	100
Goat Anti Mouse IgG (H+L): 40nm OD10 100ml	CC.GAM40/7	100
Goat Anti Mouse IgG 40nm OD10 500ml	BA.GAM40/8	500
Goat Anti Mouse IgG (H+L): 40nm OD10 500ml	CC.GAM40/8	500
Goat Anti Mouse IgM 40nm OD10 5ml	BA.GAMM40/X	5	Anti-mouse IgM
Goat Anti Mouse IgM 40nm OD10 100ml	BA.GAMM40/7	100
Goat Anti Mouse IgM 40nm OD10 500ml	BA.GAMM40/8	500
Goat Anti Rabbit IgG 40nm OD10 5ml	BA.GAR40/X	5	Anti-rabbit IgG
Goat Anti Rabbit IgG 40nm OD10 100ml	BA.GAR40/7	100
Goat Anti Rabbit IgG 40nm OD10 500ml	BA.GAR40/8	500

Please contact us for availability of 500ml package sizes.

Protein Gold Conjugates - EM grade

Product description	Product code	Package size (ml)	Particle size (nm)	Protein
Bovine Serum Albumin 10nm - 0.25ml	EM.BSA10/1	0.25	10	Bovine Serum Albumin (BSA)
Bovine Serum Albumin:15nm -0.25ml	EM.BSA15/1	0.25	15
Bovine Serum Albumin: 20nm -0.25ml	EM.BSA20/1	0.25	20
Bovine Serum Albumin: 40nm -0.25ml	EM.BSA40/1	0.25	40
Bovine Serum Albumin 10nm -1ml	EM.BSA10/2	1	10
Bovine Serum Albumin:15nm -1ml	EM.BSA15/2	1	15
Bovine Serum Albumin: 20nm -1ml	EM.BSA20/2	1	20
Bovine Serum Albumin: 40nm -1ml	EM.BSA40/2	1	40
Protein A: 10nm Gold -0.25ml	EM.PAG10/1	0.25	10	Protein A
Protein A: 15nm Gold -0.25ml	EM.PAG15/1	0.25	15
Protein A: 10nm Gold -1ml	EM.PAG10/2	1	10
Protein A: 15nm Gold -1ml	EM.PAG15/2	1	15
Streptavidin: 5nm -0.25ml	EM.STP5/1	0.25	5	Streptavidin
Streptavidin: 10nm -0.25ml	EM.STP10/1	0.25	10
Streptavidin: 20nm -0.25ml	EM.STP20/1	0.25	20
Streptavidin: 5nm -1ml	EM.STP5/2	1	5
Streptavidin:10nm -1ml	EM.STP10/2	1	10
Streptavidin: 20nm -1ml	EM.STP20/2	1	20

Lateral Flow Controls Gold conjugated - Particle size 40nm

Protein Gold Conjugates - Particle size 40nm

Product description	Product code	Package size (ml)	Protein
Bovine Serum Albumin 40nm OD10 5ml	BA.BSA40/X	5	Bovine Serum Albumin (BSA)
Bovine Serum Albumin 40nm OD10 100ml	BA.BSA40/7	100
Bovine Serum Albumin 40nm OD10 500ml	BA.BSA40/8	500
Protein A 40nm OD10 5ml	BA.PAG40/X	5	Protein A
Protein A 40nm OD10 100ml	BA.PAG40/7	100
Protein A 40nm OD10 500ml	BA.PAG40/8	500

Immunoglobulins Gold conjugated - Particle size 40nm

Product description	Product code	Package size (ml)	Immunoglobulin
Chicken IgY 40nm OD10 5ml	CONT.CHICK/X	5	Chicken IgY
Chicken IgY 40nm OD10 100ml	CONT.CHICK/7	100
Chicken IgY 40nm OD10 500ml	CONT.CHICK/8	500
Mouse IgG 40nm OD10 5ml	BA.MG40/X	5	Mouse IgG
Mouse IgG 40nm OD10 100ml	BA.MG40/7	100
Mouse IgG 40nm OD10 500ml	BA.MG40/8	500

Please contact us for availability of 500ml package sizes.

Anti-Hormone antibodies - Gold conjugated - Particle size 40nm

Product description	Product code	Package size (ml)	Hormone
Monoclonal Anti HCG 40nm OD10 5ml	BA.HCG40/X	5	Human chorionic gonadotropin (hCG)
Monoclonal Anti HCG 40nm OD10 100ml	BA.HCG40/7	100
Monoclonal Anti HCG 40nm OD10 500ml	BA.HCG40/8	500
Monoclonal anti-LH 40nm OD10 5ml	BA.LH40/X	5	Luteinizing hormone (LH)
Monoclonal anti-LH 40nm OD10 100ml	BA.LH40/7	100	Luteinizing hormone (LH)

Please contact us for availability of 500ml package sizes.

Gold Colloid

BBI Solutions trusted colloidal gold nanoparticles are used in over 500 million assays a year. We set the standard for your assay needs, batch after b...

Lateral Flow Development

For over 30 years , BBI Solutions has been a trusted OEM partner for the development and manufacture of lateral flow assays. Our robust and agile late...

Lateral Flow Manufacturing

BBI Solutions offers robust and flexible manufacturing options for your lateral flow assays. Our manufacturing options cater not only to routine manuf...

Custom Monoclonal Antibody Development

BBI Solutions provides custom monoclonal antibody development services, covering the design of a custom strategy and project plan all the way through ...

Gold Conjugation Services

BBI Solutions has over 30-years of experience in the development of reliable lateral flow assays, and one of the most important factors is the quality...

Gold Conjugates FAQs

Our team are here to help! If you can’t find the answer you are looking for please contact us

The antibodies are passively conjugated to the gold nanoparticle surface (no covalent or linker chemistry is used). Protein binds to gold colloid through amino acid residues: charge attraction (lysine), hydrophobic attraction (tryptophan), and sulphur bonding (cysteine).

IgG is the most popular isotype for conjugation and can be conjugated with a high success rate. The antibody binds to the gold nanoparticles through the Fc region, leaving the Fab region exposed and able to bind the antigen of interest. IgG3 antibodies are more difficult to work with so these should be avoided if possible.

IgM conjugations have a lower success rate. Cross-linking can occur when they are conjugated, and the Fc regions cannot always be exposed without damaging the integrity of the antibody.

IgE antibodies are raised in an allergic response, these antibodies can be conjugated to gold nanoparticles.

IgY antibodies are functionally similar to IgG antibodies and these can be conjugated to gold nanoparticles with a high success rate.
Antigen conjugations are possible, although the success rate is lower.

BBI can also conjugate other proteins, antibody fragments- Fab, Fc, ScFv and nanobodies.

The majority of gold conjugates (BA Grade and Custom Conjugates) are presented in a low molarity disodium tetraborate buffer.

EM grade conjugates are presented in a Tris-buffer saline solution containing 30% glycerol.

EM Grade gold conjugates can be frozen for long term storage and thawed for usage as these conjugates contain glycerol in their final buffer. Multiple freeze/ thaw cycles should be avoided.

BA Grade and Custom conjugates cannot be frozen. Freezing of these products will cause the gold nanoparticles to completely and irreversibly aggregate and should be avoided.

It is recommended to store the gold conjugates (BA Grade and Custom Conjugates) at 2-8°C. EM Grade conjugates can be kept frozen at -20°C for long term storage.

BA refers to BioAssay. These conjugates are stock products which are routinely manufactured at BBI Solutions. These are most commonly used in lateral flow diagnostic tests. The particle size is 40nm.

CC refers to custom conjugates. These conjugates are similar to BA Grade conjugates but are usually manufactured on a custom basis by request of a customer. The particle size most commonly used is 40nm.

EM refers to Electron Microscopy. These conjugates are different to BA and CC conjugates, are usually made with smaller nanoparticles and are most often used in electron microscopy. The particle size most commonly used is 10nm.

EM refers to Electron Microscopy. These conjugates are different to BA and CC conjugates, are usually made with smaller nanoparticles and are most often used in electron microscopy. The particle size most commonly used is 10nm.

In BBIs experience, 40nm is a good starting point for lateral flow development as it provides good signal visibility whilst encountering relatively little steric hindrance.

Other particles sizes may provide enhanced results depending on final application.

Our gold nanoparticles have a high level of single particle dispersion.

40nm conjugates are tested using the MonoDispersity Index (MDI). MDI uses UV-Vis readings to assess the ratio achieved between the A520nm (absorbance at which 40nm OD readings are taken) and A600nm (associated with stability) of the conjugate. A pass/ fail criterion is assigned to the ratio which is deemed acceptable to produce a stable product.

Other gold nanoparticle sizes are assessed using Transmission Electron Microscope (TEM) to assess aggregation of the particles. This is a key indicator for the stability of the product.

EM Grade conjugates are available in 0.25ml and 1ml pack sizes.

BA Grade conjugates are available in 5ml, 100ml and 500ml pack sizes. 5ml will be for samples only.

Custom conjugates are available in any pack size. Minimum order volume is usually 5ml. For orders >500ml, individual pack sizes do not exceed 500ml.

The expiry date is stated on the label of each batch. In general BA Grade conjugates have a shelf life of 2 years from the point of manufacture when stored at 2-8°C. The product will have a minimum of 6 months left on the shelf life on the date of dispatch from BBI. The shelf life of our BA conjugates was assessed by real time stability studies with a set end point, not to the point of failure. The product may still be functional after the expiry date, but the product would be used at the customer’s own risk.

BA.GAM40 stability studies are ongoing- this is currently not supplied with an expiry date.

No expiry date is applied to EM Grade conjugates. Anecdotally, these have been used 5+ years after the date of manufacture with no loss of functionality.

No expiry date is applied to Custom Conjugates, unless at request of the customer. A cost would apply for the panel of work required to assign an expiry date.

The gold conjugates are manufactured at our ISO13485:2016 certified facility in Crumlin, South Wales, UK.

Your inputs, following discussion of your application with our team,

▪ Selected detector protein (antibody/protein). Supplied by customer or BBI can source and recharge the customer.
▪ Identify target sensitivity
▪ Identify particle size
▪ Concentration of final conjugate required
▪ Provide 3-5mg of protein for conjugation and QC materials (capture, target antigen). Antigen no
more than Cat II Biohazard level

BBI outputs

▪ Initial 5-10ml of final conjugate – (enough for 1000 prototype lateral flow strips*)*using a 1:5
dilution of OD10 conjugate per strip
▪ Excess reagents banked for future production
▪ Full laboratory report on performance customised to your requirements
▪ Access to technical team post conjugation

For a custom conjugation to a 40nm particle, BBI request 3mg antibody/protein. Minimum concentration 1.0mg/mL. This allows for a full assessment of conjugation parameters prior to committing material to a batch.

Antibody quantity will be slightly more for smaller particle sizes and for alternative detectors (e.g. antigens).

Initial antibody requirement may be higher than expected but the benefit is gained as conjugate production volume increases. Antibody mg per ml of conjugate is lower with BBI’s manufacture method which is designed with long-term scale-up in mind up to 24L OD10 equivalent.

Antibody pI- this helps with assessment of conjugation parameters

Antibody source- Monoclonal/Polyclonal/Human/Recombinant. This will determine how we assess the antibody pre-conjugation.

Antibody subtype- this helps with assessment of conjugation parameters

Antibody buffer- no thimerosal in antibody buffer- this can affect binding

Antibody Supplier- considerations around robust long-term supply, availability of multiple lots

Assay format- Sandwich/Competitive/Inhibition/Serological/Non Lateral Flow- different assay formats require different considerations around conjugation parameters.

All testing is performed in liquid format.

OD at 520nm- measure of concentration

Dipstick Testing- either anti-species or specific functional system if provided. Determines performance compared to approved past batches.

Free Antibody Check- identify if free antibody is in solution that could interfere with assay.

Mono Dispersity Index (MDI)- for 40nm conjugates. A spectral reading as an indicator of potential conjugate stability.

Cluster Check – for conjugate sizes other than 40nm- indicator of potential conjugate stability. A visual count of particles under TEM to check for clustering of particles that may impact stability, performance, and reproducibility.

It is always best to perform in-process assessment and final QC testing with specific functional materials. This is not always possible if material stocks are low or costs high.

BBI requests 0.5mg capture at minimum concentration of 1.0mg/mL.

BBI request approx. 0.1-0.2mg antigen/analyte at 0.1mg/ml (minimum concentration), along with SDS or details of hazards and disposal.

No materials above Biohazard Level II are permitted.

BBI can perform stability studies on liquid conjugates at customer request. Please contact us for a quote.

Stability in customer’s final assay will be their own responsibility.

Following assessment of conjugate batches in the intended final format by the customer, further optimisation of parameters and conjugate formulation may be required. Prior to validation in customer final application, BBI recommend multiple antibody/ protein lots be conjugated and assessed to ensure robustness in manufacture.

BBI encourages feedback from conjugation events to determine improvements to conjugate formulation to achieve desired performance. This can take the format of emails, presentations or technical calls.

All OD measurements are taken in a 1ml cuvette in a UV-Vis spectrophotometer. The spectrophotometer is blanked with purified water prior to sample being read. The absorbance is the multiplied by the dilution factor to get the final OD.

Final OD10 – Conjugate is diluted 1 in 10 in purified water (10 x dilution factor)
Final OD20 – Conjugate is diluted 1 in 20 in purified water (20 x dilution factor)
Final OD40 – Conjugate is diluted 1 in 40 in purified water (40 x dilution factor)

Gold Colloid

BBI Solutions trusted colloidal gold nanoparticles are used in over 500 million assays a year. We set the standard for your assay needs, batch after b...

Lateral Flow Development

For over 30 years , BBI Solutions has been a trusted OEM partner for the development and manufacture of lateral flow assays. Our robust and agile late...

Lateral Flow Manufacturing

BBI Solutions offers robust and flexible manufacturing options for your lateral flow assays. Our manufacturing options cater not only to routine manuf...

Custom Monoclonal Antibody Development

BBI Solutions provides custom monoclonal antibody development services, covering the design of a custom strategy and project plan all the way through ...

Gold Conjugation Services

BBI Solutions has over 30-years of experience in the development of reliable lateral flow assays, and one of the most important factors is the quality...

Gold Conjugation- why quality gold matters

One of the most important factors in the development of a reliable assay is the quality of the gold conjugate. At BBI Solutions, we use the highest quality grades of gold nanoparticles and apply our unique conjugation protocol to deliver an optimised product that meets the demands of your assay.

Whether you are looking to bind gold to a specific antibody and need a custom conjugation, or off the shelf products, BBI can help and deliver.

Custom conjugation service from BBI Solutions

Our custom conjugation service allows us to develop high-quality conjugates using reagents provided by you or sourced by us.

Our service includes:

Advice on the optimum nanoparticle and size to use for your application	Conjugation of your antibody or protein to a nanoparticle and size of your choice
Particle Analysis	Batch sizes up to 24L at OD10
Sourcing your required antibody or protein	Long term stability analysis (on request)
Selection of appropriate final buffer for the conjugate	Custom OD preparation (not limited to OD10)
Antibody Screening	QC test development
Optimisation of sensitivity and potential stability	Comprehensive lab report on conjugate performance

Designed to meet your individual needs

Specificity, sensitivity and reproducibility should define the specification and fulfil your absolute minimum expectations of the conjugate.

Our scientists work in partnership with customers to bring all the vital ingredients together and provide sensitive, stable, reproducible conjugates time after time.

At the start of the project we will ask you for the following customer inputs and deliver the listed outputs:

Customer inputs	BBI outputs
Choose your target protein (antibody/protein)	Initial 10ml of final optimised product – (enough for 1000 prototype lateral flow strips*)
Identify target sensitivity	Excess reagents banked for future production
Identify particle size	Full laboratory report on performance customised to your requirements
Concentration of final conjugate required	Access to technical team post conjugation
Provide 3-5mg of protein for conjugation and QC materials	*using a 1:5 dilution of OD10 conjugate per strip

A quality solution

Every custom conjugation is QC tested with customer supplied materials. Your unique sign-off procedure is brought into BBI to ensure every batch of gold we deliver meets your requirements and works with your in-house system.

Bulk production

Following collaboration on the optimisation of the conjugate to test specifications, we are able to provide conjugate in bulk. We can put a commercial supply plan in place and supply single batch volumes of up to 24l at OD10, delivered on a two-week turnaround.

To find out more about our conjugation service, contact us »

Off the shelf conjugates

For optimal performance, cost effectiveness and guaranteed quality, we offer off the shelf catalogue gold conjugates, designed to help you develop and manufacture your assay at a rapid and economical rate.

Our catalogue range includes:

Anti-biotin
Anti-human
Control line
Anti-species
Disease state conjugates
Fertility conjugates

All conjugates are manufactured using our unique gold nanoparticles, providing outstanding performance and long term stability.

If you are looking for a conjugate which is not in our standard product range, please contact us with your requirements.

Anti-Biotin	Anti-Human	Control line	Anti-species	Fertility
Monoclonal anti Biotin 40nm	Goat anti Human IgG (H+L) 40nm	Chicken IgY 40nm	Goat anti Rabbit 40nm	Human Chorionic Gonadtrophin (HCG) 40nm
Goat anti Biotin 40nm	Goat anti Human IgG 40nm	Mouse IgG 40nm	Goat anti Mouse IgG (H+L) 40nm	Human Lutienizing Hormone (LH) 40nm
	Goat anti Human IgM 40nm	Bovine Serum Albumin 40nm *
	Goat anti Human IgA 40nm	Goat anti Mouse IgG (H+L) 40nm
	Protein A 40nm	Goat anti Rabbit 40nm

*Negative control conjugate

Gold Conjugates for Microscopy

Gold labels offer an effective method of labelling antigens for visualisation in the electron microscope. BBI has a range of EM grade conjugates that combine different antibodies on a range of particles, predominantly 2, 5, 10, 15, 20, 30 & 40nm. For researchers beginning to work with immunogold labelling, we recommend 10nm gold conjugates for observation, at a range of magnifications.

Our technical team are available to discuss which conjugate is right for your application or to answer your nanoparticle based questions here.

Applications

BBI Solutions’ gold nanoparticles are renowned for their use in lateral flow tests; however, the use of nanoparticles ranges from health and material technology to the environment and energy sectors.

The technology sectors and applications listed below provide a summary of where our gold nanoparticles are being used by our customers and partners:

Size range of nanoparticles	Area of use	Function
Small (2nm -15nm)	Immunohistochemistry Light Microscopy High magnification TEM Biomarkers High throughput microarray platforms	Antibody/antigen detection in cells Detection of biomarkers in cells for imaging and sensing Blood typing SDS screening
Medium (20nm – 80nm)	Lateral flow assays TEM and SEM Biomarkers SERS DNA detection	Detection of food borne pathogens Bacteria in blood Drugs of abuse Clinical biomarkers Veterinary biomarkers Mycotoxin detection
Large (80nm – 250nm)	Flow cytometry SERS Forensic science	Detection of CD4 cells using flow cytometry Clinical biomarker detection using Raman spectroscopy