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Infectious Disease Antigens

Why Infectious Disease Antigens from BBI?

For our infectious disease antigens, we offer a selected range targeting specific viral and bacterial proteins derived using molecular methods and using carefully chosen recombinant expression systems. Products are made to order or available from stock using processes defined by specific batch records. We endeavour to always supply material to our customers’ timelines but rely on our clients to provide forecasts and estimates of usage. 

Materials are prepared using a range of purification technologies, some of these unique to BBI.  Products are available highly purified and are formulated to optimise shelf-life. We provide material in the most convenient storage format, often stored in ultra-cold systems to ensure maximum shelf-life.

 Analytical testing is performed to demonstrate the product purity and recovery using immunological and/or biochemical protein assays.  Products are often tested with or referenced against specific stored patient samples to ensure the performance.

Please contact our Customer Services Team directly to discuss your requirements on tel:+44 (0) 1495 363000 or alternatively you can submit an enquiry here.

Disease Area	Product	Product code	Quantity
Anaplasmosis	Anaplasma phagocytophilum Msp5	45600 45601	0.1 mg 1.0 mg
	Anaplasma phagocytophilum OmpA	45800 45801	0.1 mg 1.0 mg
	Anaplasma phagocytophilum p44	45500 45501	0.1 mg 1.0 mg
Babesiosis	Babesia microti IRA	44200 44201	0.1 mg 1.0 mg
	Babesia microti p32	44100 44101	0.1 mg 1.0 mg
	Babesia microti p41	44000 44001	0.1 mg 1.0 mg
Bartonellosis / Cat Scratch Disease	Bartonella henselae 17 kDa	45000 45001	0.1 mg 1.0 mg
	Bartonella henselae 26 kDa	45100 45101	0.1 mg 1.0 mg
	Bartonella henselae SucB	45200 45201	0.1 mg 1.0 mg
Borreliosis / Lyme Disease	Borreliella afzelii BmpA	41100 41101	0.1 mg 1.0 mg
	Borreliella afzelii DbpA	40900 40901	0.1 mg 1.0 mg
	Borreliella afzelii OspA	41000 41001	0.1 mg 1.0 mg
	Borreliella afzelii OspC	41800 41801	0.1 mg 1.0 mg
	Borreliella afzelii p100	42300 42301	0.1 mg 1.0 mg
	Borreliella bavariensis DbpA	42700 42701	0.1 mg 1.0 mg
	Borreliella bavariensis p58	40700 40701	0.1 mg 1.0 mg
	Borreliella bavariensis VlsE1	41400 41401	0.1 mg 1.0 mg
	Borreliella burgdorferi BmpA	40500 40501	0.1 mg 1.0 mg
	Borreliella burgdorferi DbpA	40400 40401	0.1 mg 1.0 mg
	Borreliella burgdorferi DbpB	40600 40601	0.1 mg 1.0 mg
	Borreliella burgdorferi NapA	41300 41301	0.1 mg 1.0 mg
	Borreliella burgdorferi OspA	41200 41201	0.1 mg 1.0 mg
	Borreliella burgdorferi OspC	40300 40301	0.1 mg 1.0 mg
	Borreliella burgdorferi p28	42500 42501	0.1 mg 1.0 mg
	Borreliella burgdorferi p30	42600 42601	0.1 mg 1.0 mg
	Borreliella burgdorferi p41	40200 40201	0.1 mg 1.0 mg
	Borreliella burgdorferi p45	41500 41501	0.1 mg 1.0 mg
	Borreliella burgdorferi p58	41600 41601	0.1 mg 1.0 mg
	Borreliella burgdorferi p66	41700 41701	0.1 mg 1.0 mg
	Borreliella burgdorferi p100	40100 40101	0.1 mg 1.0 mg
	Borreliella burgdorferi VlsE1	45700 45701	0.1 mg 1.0 mg
	Borreliella garinii DbpA	42800 42801	0.1 mg 1.0 mg
	Borreliella garinii OspC	41900 41901	0.1 mg 1.0 mg
	Borreliella spielmanii DbpA	42900 42901	0.1 mg 1.0 mg
	Borreliella spielmanii OspC	40800 40801	0.1 mg 1.0 mg
COVID-19	SARS-CoV-2 Nucleocapsid (N) Protein	46000 46001	0.1 mg 1.0 mg
COVID-19	SARS-CoV-2 Spike (S) Glycoprotein RBD	46100 46101	0.1 mg 1.0 mg
Relapsing fever	Borrelia miyamotoi GlpQ	42400 42401	0.1 mg 1.0 mg
Erythema infectiosum	Parvovirus B19 VLP VP2	48000 48001	0.1 mg 1.0 mg
Erythema infectiosum	Parvovirus B19 VLP VP1/VP2 Co-Capsid	48100 48101	0.1 mg 1.0 mg
Yersiniosis	Yersinia enterocolitica (O:8) YopM	43000 43001	0.1 mg 1.0 mg
	Yersinia enterocolitica (O:9) LcrV	43100 43101	0.1 mg 1.0 mg
	Yersinia enterocolitica (O:9) YopB	43200 43201	0.1 mg 1.0 mg
	Yersinia enterocolitica (O:9) YopD	43300 43301	0.1 mg 1.0 mg
	Yersinia enterocolitica (O:9) YopE	43700 43701	0.1 mg 1.0 mg
	Yersinia enterocolitica (O:9) YopH	43400 43401	0.1 mg 1.0 mg
	Yersinia enterocolitica (O:9) YopM	43500 43501	0.1 mg 1.0 mg
	Yersinia enterocolitica (O:9) YopN	43600 43601	0.1 mg 1.0 mg
HIV	HIV p24 antigen (recombinant)	P714-3	0.1 mg

Sars-Cov-2

In December 2019, a new severe respiratory disease emerged in the province of Wuhan, China. Later, a novel coronavirus (CoV) named Severe Acute Respir...

Infectious Disease

At BBI Solutions, we offer a diverse range of monoclonal antibodies against an expansive range of infectious disease targets to ensure the reliability...

Antigens FAQs

Our team are here to help! If you can’t find the answer you are looking for contact us

For our European customers please contact your BBI sales representative or reach out to our customer services team. For our US and Asia customers you can also contact your BBI representative for support however sales enquiries, where relevant, will be routed through a local representative. In the US for DIARECT catalogue products, these should be ordered from our US distribution partner Surmodics.

Upon receipt, our antigens / antibodies should be stored frozen at - 70°C or below until use. We recommend thawing at room temperature, but thawed products should not remain at room temperature for extended periods of time. Mix products gently before use. If you plan on using only a portion of the product, please thaw and dispense it into aliquot volumes that are most practical for your application and store frozen at - 70°C or below. Please note that we cannot guarantee the shelf life after the antigens / antibodies have been re-dispensed and adviceagainst repeated freeze thaw cycles.

While general recommendations for antigen / antibody storage conditions and buffers are given in the antigen's / antibody's specification sheet, which can be found in the “+INFO” section associated with each antigen / antibody on DIARECT's website, the detailed buffer composition is available together with the lot-specific Certificate of Analysis (CoA).

No, we do not recommend using antigens / antibodies without a guaranteed cold chain. If you receive a thawed product please inform our customer service immediately. Regarding dry ice shipments please visit section "shipping information" on our website for detailed information on temperature tests.

For each antigen / antibody, DIARECT created a “+INFO” section on its website, which contains the antigen's / antibody's material safety data sheet (MSDS) and specification sheet. The latter provides
general recommendations regarding antigen / antibody storage and buffers. For select antigens / antibodies, the documents section also contains a brochure offering some background information and immunological test data. You can also contact your local representative or info-dia@bbisolutions.com for more details.

Most of our antigens have a guaranteed shelf life of five years unless otherwise noted on our Certificates of Analysis (CoA) and data sheets, and providing that they are kept frozen at -70°C or
below. For the shelf life of our antibodies, please check the expiry date on the lot-specific CoA provided with the product.

We guarantee the reservation of a specified amount of antigen(s). Typically, customers reserve the amount of antigen(s) needed for a manufacturing period of up to 18 months. You simply inform us of your antigen requirements for this period, and every 4 months you will receive an updated overview regarding the accuracy of your estimate. The reservation system also includes the allocation of early enough samples of new lots of the respective antigen(s). This enables the customer to evaluate the new lot at an early stage for future reservations and allows a smooth transition to this new lot. Advantages provided by DIARECT's reservation system:
- Security of supply with no additional costs
- No need for continual readjustment and fine tuning of your assay because of new antigen lots

BV and Ec represent the type of expression system that was used to produce the antigen of interest. BV stands for DIARECT's baculovirus/insect cell expression system, while Ec stands for DIARECT's E. coli expression system.

For purification, the preferred technique is the very effective, yet gentle immobilized metal-ion affinity chromatography (IMAC) in combination with His-tag technology, which yields physiologically and immunologically active proteins. Our native proteins are purified using appropriate standard chromatography purification methods including ion exchange, size exclusion and immunoaffinity.

DIARECT's recombinant and native antigens / antibodies - always produced according to documented procedures (SOPs) and manufactured per EN ISO 13485 and 9001 standards - undergoing a rigorous series of tests in our quality control laboratory. Prior to its approval and release, each lot is subjected to various biochemical and immunological analyses to assure conformance to our strict product specifications. The goal of these extensive inspections is to ensure lot-to-lot conformance, which guarantees consistent results.

General information regarding the origin and expression constructs of antigens are provided in the respective specification sheets, however, exact sequence data are considered proprietary information. Most recombinant antigen preparations are supplied with a 6xHis-tag as part of the sequence.

DIARECT antigens are manufactured in our EN ISO 13485 audited facility in Freiburg, Germany. Supply is either direct from our Freiburg facility or may be managed by our local representatives in specific territories.

If you would like information about price, ordering of samples or placing an order please submit your enquiry via the contact us form or alternatively contact us via info-dia@bbisolutions.com

For further technical information about our products please contact our technical team on technicalsupport@bbisolutions.com.

Sars-Cov-2

In December 2019, a new severe respiratory disease emerged in the province of Wuhan, China. Later, a novel coronavirus (CoV) named Severe Acute Respir...

Infectious Disease

At BBI Solutions, we offer a diverse range of monoclonal antibodies against an expansive range of infectious disease targets to ensure the reliability...

High specificity disease state Antigens

The focus for our range of infectious disease antigens has been to derive targets for specific disease states where a high quality and high specification reproducible product is required to give the best performance across different assay platforms. The antigens offered have been designed after careful consideration of the target organism proteome and the proteins have been selected based on rigorous testing.

BBI derives its range of infectious disease antigens by molecular methods and the proteins are expressed in specific host organisms. The host cell lines are stored and propagated in our specific bioreactor systems. Some of our recombinant products are expressed with specific His-tag sequences to facilitate purification by nickel chelate affinity chromatography. Other materials are purified by a series of different chromatography techniques. The purified proteins are then formulated liquid or lyophilised in the most appropriate stabilising buffer and filtered to 0.2µm to ensure low bioburden. 

Products are characterised prior to fill to determine the recovery and purity of the protein using a range of analytical techniques. Techniques such as Coomassie stained SDS-PAGE are used to test and verify the product purity. After the products have been filled and formulated, they are retested by our independent Quality Control laboratory to verify the analytical results and define the biological integrity. 

Global Supply

Materials are stored and shipped from our Sittingbourne or Freiburg facilities. Materials produced at our Sittingbourne facility are shipped directly to all our customers in all territories worldwide. Antigens prepared at our Freiburg facility are supplied directly to clients in Europe and non-China Asia territories.  For customers in America and China our Freiburg antigens are distributed through our carefully selected and highly reputable partners.

BBI has a range of specific infectious disease antigen products which are supplied as standard products from stock, plus there are several products that we make to order. As we are the manufacturer, we can provide the most cost-effective solution for our clients.