Biosensor header.jpg
Biosensors thumbnail.jpg

Biosensor

Marketing leading Enzymes from BBI Solutions  

With a strong history of innovation and quality, BBI Solutions specialises in the extraction and purification of enzymes and related biochemicals from microbial, animal and plant tissues. We have been supplying the medical diagnostics, healthcare, and pharmaceutical industries for over 50 years.  

In this time, we have developed effective, reliable and high-quality products that are used by industry leaders across the world. With international multi-site manufacturing facilities and worldwide distribution capabilities supplying a truly global and diverse customer base, BBI Solutions is the partner of choice for your reagents. 

BBI Solutions manufacture a diverse range of consistent high-quality enzymes derived from microbial, animal and plant tissues. Our enzymes, including our market-leading glucose oxidase, alkaline phosphatase and horseradish peroxidase, are renowned for their leading levels of activity and purity with a proven performance in a variety of critical diagnostic applications.  

Over 50 years of enzyme expertise 

Our enzymes have been used by the diagnostics industry for over 50 years, within a wide range of applications, including: 

  • Biosensors 
  • Immunoassays 
  • Clinical chemistry 
  • Pharmaceutical 
  • Molecular 
  • Research 

Core Competencies  

Large product range 

Our product range includes enzymes for biosensor, immunoassay, clinical chemistry, molecular and pharmaceutical applications with a range of different grades to suit all applications.  

Quality  

We aim to develop, manufacture and supply high quality enzymes which meet both customer and regulatory requirements.  

Stability

We use quality raw materials, innovative production methods and product formulations to achieve maximum stability for our products.  We test our products regularly to ensure this remains consistent.  

Custom manufacture  

If one of our off-the-shelf products does not meet your requirements, we can offer custom development and manufacturing services to deliver an enzyme to your specification, perfect for your application. 

BBI’s capabilities 

  • Specialists in sourcing and extraction of animal and plant products – we have extensive experience in sourcing raw materials worldwide  
  • Salt/solvent fractionation – batch sizes of up to 5,000 litres 
  • Chromatography – ion exchange chromatography, affinity chromatography, size exclusion chromatography, hydrophobic interaction chromatography  
  • Crystallisation – highly effective protein purification using solvent and aqueous media  
  • Ultrafiltration – volumes of 2,500 - 30,000 litres  
  • Freeze drying – capability of 49 - 420 litres per cycle  
  • Quality control – in-process analysis and monitoring, development of assay/test procedures  
  • Product handling/sampling – we offer special packing according to customer specifications 

Please contact our Customer Services Team directly to discuss your requirements on tel:+44 (0) 1495 363000 or alternatively you can submit an enquiry here.

 

Enzymes FAQs

Our team are here to help! If you can’t find the answer you are looking for please contact us.

The material is manufactured in our ISO 13485:2016 compliant facility in Crumlin, South Wales, UK. Horseradish peroxidase and Ribonuclease are made at the ISO13485:2016 complaint facilities in Crumlin, South Wales, UK and Cape Town, South Africa.

Some products can have their best before date extended beyond that stated on the ADS which arrives with the product. Contact technicalsupport@bbisolutions.com to check if the date can be extended.

• Biosensors
• Immunoassays
• Clinical chemistry
• Molecular diagnostics

BBI Solutions’ Alkaline Phosphatase (ALP) is extracted from bovine intestine then purified using multiple precipitation, fractionation, chromatography and filtration steps.

ALP is commonly used as a label in immunoassays such as ELISA, and in blotting and histochemistry. Once conjugated to antibodies, antigens, or streptavidin, its low backgrounds and linear reaction rate enables increased sensitivity over extended incubation times. It can be used with a variety of substrates producing precipitated or soluble chromogens, or with chemiluminescent and fluorogenic substrates for enhanced sensitivity.

Our high activity conjugation grade products are supplied as glycerol solutions.

We recommend you store the material between 2 - 8°C. This product is shipped at ambient temperature.

BBI grade ALPI12G, which has the highest specific activity currently available.

Guaranteed quality: ALP is manufactured under our Quality System compliant with ISO 13485:2015, with stringent QC analysis for every batch.
• Highest activity ALP on the market: >2000 glycine U/mg protein and >6000 DEA U/mg protein, for some batches we achieve >2300 and >7000.
• High stability: Less than 10% activity lost over 48 months.• Proven performance: We have benchmark data demonstrating proven performance against the competition.
• Multiple grades: We offer various ALP products with defined activities, enabling you to select an enzyme which best suits your application.
• Bulk extraction and purification capability: Our optimised large-scale manufacturing processes produce high volumes of all grades.

We typically pack to order and can supply any quantity from 10ku to >10,000ku.

BBI’s Glucose Oxidase is produced from large-scale fermentation of the fungus Aspergillus niger. The crude fermentation liquor is purified using multiple precipitation, fractionation, chromatography, and filtration steps.

Glucose Oxidase is used in liquid and powder glucose laboratory reagents, urine test strips, colorimetric blood glucose strips and for blood glucose monitoring in biosensors.

Our final products are lyophilised powders.

We recommend you store the material desiccated at -15°C or below. This product is shipped at ambient temperature.

• Guaranteed quality: Glucose Oxidase is manufactured under our Quality System compliant with ISO 13485:2015, with stringent QC analysis for every batch.
• Greater accuracy: Highest levels of activity and purity to increase speed and accuracy
• Choice and flexibility: Multiple grades and custom preparations available for specific applications to optimise your assay at reduced cost
• Proven performance: Enabling strip manufacturers to comply with the latest accuracy guidelines (+/- 15%)
• Batch to batch reproducibility and consistency: Optimised and controlled manufacturing procedures to ensure reproducibility and consistency – essential in high volume strips
• High manufacturing capacity: BBI has bulk manufacturing capabilities

We typically pack to order and can supply any quantity from 1MU to >1,000MU.

BBI’s Peroxidase is extracted from horseradish roots then purified using multiple precipitation, fractionation, chromatography and filtration steps.

Horseradish Peroxidase (HRP) is used in a wide range of liquid clinical chemistry reagents, dry powder reagents and test strips It is also commonly used as a label in immunoassays such as ELISA, and in blotting and histochemistry. Once conjugated to antibodies, antigens, or streptavidin, its rapid turnover rate gives high sensitivity over short incubation times.

Our final products are lyophilised powders.

We recommend you store the material desiccated at -15°C or below. This product is shipped at ambient temperature.

• Guaranteed quality: HRP is manufactured under our Quality System compliant with ISO 13485:2015, with stringent QC analysis for every batch.
• Controlled and consistent supply: We have developed close relationships with horseradish growers to ensure planned purchase of specially selected and cultivated horseradish roots
• High isozyme C content: Material available above 90%
• High activity levels: ~280 U/mg
• Highly available amino groups: For clean conjugation
• Bulk extraction capability: Our optimised large-scale manufacturing processes produce high volumes of both clinical chemistry and immunoassay grades

We typically pack to order and can supply any quantity from mg to kg depending on the grade required.

BBI’s Ribonuclease is extracted from bovine pancreas using multiple precipitation, fractionation, chromatography and filtration steps.

Ribonuclease can be used in the following applications:
• In isolation of DNA for RNA-free DNA, especially plasmid DNA• Structural studies of RNA
• The depolymerisation of viscous biological suspensions, rendering RNA-free solutions

Our final products are lyophilised powders.

We recommend you store the material desiccated at -15°C. This product is shipped at ambient temperature.

• Guaranteed quality: RNase is manufactured under our Quality System compliant with ISO 13485:2015, with stringent QC analysis for every batch.
• Proven performance: In DNA extraction kits
• Batch-to-batch reproducibility: Enabling consistent formulations
• Bulk extraction and purification capability: Our optimised large-scale manufacturing processes produce high volumes of purified RNase
• Secure supply: We have direct relationships with our raw material suppliers to ensure a secure supply chain

We typically pack to order and can supply any quantity from g to kg.

BBI’s urease is obtained from specially selected and cultivated jack beans. The enzyme is extracted from the beans then purified using multiple precipitation, fractionation, chromatography and filtration steps.

Urease is used in liquid and powder urea laboratory reagents, and biosensors. It can be used in the determination of urea in biological fluids (couple with GLDH, in the ultraviolet method). Urease can also be used as an enzymes label in ELISA.

Our final products are lyophilised powders.

We recommend you store the material desiccated at -15°C or below. This product is shipped at ambient temperature.

• Guaranteed quality: Urease is manufactured under our Quality System compliant with ISO 13485:2015, with stringent QC analysis for every batch.• Proven performance: In liquid and powder reagents
• High purity: For biosensor applications
• Bulk capability: Manufacturing in high volumes to reduce cost
• Batch-to-batch reproducibility: Enabling consistent formulations
• Secure supply: We have direct relationships with our raw material suppliers to ensure a secure supply chain

We typically pack to order and can supply any quantity from 1MU to >1,000MU.

Proven delivery of market-leading Enzyme products. 

BBI Solutions is the partner of choice for anyone developing products incorporating high specification enzymes. With over 20 years’ experience supplying the biosensors market, including international multi-site manufacturing facilities and worldwide distribution capabilities, BBI offer a truly global and diverse customer experience.  

Why Use BBI Glucose Oxidase? 

BBI Glucose Oxidase demonstrates exceptional performance, not only outperforming competitors but exceeding our own claims in relation to the level of purity and activity of our enzymes. Using the best Glucose Oxidase on the market, from a proven supplier of this key raw material, allows your company to concentrate on its core competencies, benefitting your whole business and giving you peace of mind. The high activity and stability of our Glucose Oxidase means you use less enzyme per strip – reducing costs while increasing the speed, accuracy and longevity of the strip, and it’s a proven raw material – which reduces validation time. This is why the world’s leading manufacturers put their trust in BBI. 

Proven to be fast, accurate and reliable

We benchmark our material against our competitors, so we know we offer the greatest range and highest levels of purity, specificity and activity – avoiding interference and giving the user accurate results and a rapid response.  Importantly, this high quality is consistent from batch to batch which, in turn, ensures the consistent performance of your strips and reliable results from the sensor. 

When results matter...only the best will do

As a strip manufacturer you know that the enzyme is the most critical component in a sensor, so a consistently high-quality enzyme is vitally important to maximise the performance of your product. 

What makes our Glucose Oxidase the best in the world for blood glucose monitoring? 

  • Proven performance – our material is used in over 5 billion test strips every year 
  • Highest levels of activity and purity – enabling rapid test times and reducing signal interference 
  • Multiple high purity grades available – can be specified to avoid interference and provide cost effective solutions for all applications 
  • High stability during strip production and storage - BBI Glucose Oxidase is available in both proprietary and customised formulations that ensure stability in a wide variety of strip formats 
  • Batch to batch reproducibility and consistency – essential in high volume strip production 
  • Our Glucose Oxidase works on your platform – BBI Glucose Oxidase is used in numerous mediated and non-mediated sensor formats 
  • Gives high levels of accuracy in your platform - using Glucose Oxidase from BBI will enable your system to meet your accuracy requirements. The high purity GO3A has an extremely low Catalase to Glucose Oxidase ratio reducing interference and improving strip performance 
  • Reliable source – with an established and reliable supply chain at the volumes you require, saving validation time 
  • Quality guarantee – Our R&D and manufacturing facilities operate under ISO 13485:2016 and are regularly audited 

 

 

Technical Documents

If you require any further product specific technical information or datasheets please submit your request to our technical team here 

Last updated: 26/03/2021

BBI Products and Services Brochure

Last updated: 26/03/2021

BBI Solutions Enzymes Brochure

Last updated: 01/02/2021

Glucose Oxidase

Last updated: 26/03/2021

BBI Products and Services Brochure

Last updated: 26/03/2021

BBI Solutions Enzymes Brochure

There are currently no documents in this category.
Last updated: 01/02/2021

Glucose Oxidase

There are currently no documents in this category.
There are currently no documents in this category.
There are currently no documents in this category.
There are currently no documents in this category.
There are currently no documents in this category.
There are currently no documents in this category.

Request a callback

If you have any questions or wish to discuss your requirements please submit an enquiry using the form below. Our dedicated customer services team will respond directly.

Newsletter

Receive regular industry insights and the latest BBI Solutions' news & product launch information by signing up to our Newsletter