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The Natriuretic peptide family of hormones are secreted primarily from the heart, kidneys and brain that cause vasodilation and natriuresis.proBNP is cleaved on secretion into the bloodstream to produce the two biomarkers of 32-aa BNP and 76-aa NT-proBNP. NT ProBNP has a longer half-life than BNP in serum making it a preferable biomarker. BNP and NT-proBNP are released from cardiac myocytes in response to mechanical load and wall stress. Elevated levels of BNP and NT-proBNP are helpful to aid diagnosis of systemic sclerosis.