Polystreptavidin
It’s time to go beyond Streptavidin
Introducing recombinant Polystreptavidin, with more biotin binding sites, and greater sensitivity, stability and uniformity across your lateral flow tests.
Polystreptavidin is a recombinant, polymerised version of the industry standard Streptavidin that can offer an increased number of biotin binding sites, chemo/thermal stability, signal strength and assay sensitivity.
Customer testing has shown consistently superior sensitivity in lateral flow assays with better results even at lower sample concentrations.
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HOW IT WORKS
A new standard for lateral flow sensitivity
Polystreptavidin R takes the well established standards of traditional Streptavidin based assay sensitivity, and amplifies it thanks to the increased number of biotin binding sites.
Customer testing has shown consistently superior sensitivity in lateral flow assays with better results even at lower sample concentrations.
Immunodiagnostic assays are constantly evolving thanks to new technological developments.
From the Biotin-Avidin-Systems of the late 1970s, to the commonly used Streptavidivin used today, now BBI is proud to exclusively offer you the next evolution in biotin-based assay development, Polystreptavidin R.
A recombinant, polymerised version of the industry standard Streptavidin that can offer an increased number of biotin binding sites, chemo/thermal stability, signal strength and assay sensitivity.
HIGHLIGHTS
Our recombinant manufacturing process delivers best in class consistency, so you can trust in the efficacy of our Polystreptavidin in your tests.
Buy NowAs an ISO 13485 certified manufacturer you can rest assured you have access to a consistent high quality product, batch after batch, saving you time and resources.
Buy NowBBI Solutions is the exclusive supplier of Polystreptavidin R, and we understand the benefits increasing uniformity across your product development can bring.
Buy NowWe are a global leader in the primary manufacture of diagnostic reagents supplying of critical raw materials for the development of immunoassay diagnostics from concept to commercialization.
Buy NowOur experts support you every step of the way, ensuring the market success of your diagnostics solutions.
Buy NowWe've recently invested in our new Centre of Excellence, strengthening our recombinant manufacturing capabilities to fully meet our customers' needs, no matter what the scale.
Buy Nownks to the uniformity of its surface coating and the exceptionally low washout effects, you can expect significant signal enhancement at the test line from your Polystreptavidin R based assays.
Buy NowThanks to the polymeric nature of Polystreptavidin R, you can achieve a higher density of Streptavidin tetramers per surface area. This can allow you to use lower reagent consumption in your immuno-assay development while still maintaining signal strength.
Buy NowPolystreptavidin R comes in solution, making it easy and ready to use with no additional washing or blocking steps required. The high chemo and thermal stability make it easy to store (2 - 8°C) with a 2 year shelf life offering increased stability of the final diagnostic product.
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Testimonial
What customers say
“Polystreptavidin R has become our go-to reagent.
Both the performance and stability is unrivalled and having used multiple batches, there is no question on quality and consistency.
It is now incorporated into multiple rapid test products and our pipeline over the next 3 years and we will not hesitate to continue development of our product portfolio using it.”
– Dr Kevin Woolston
| Author(s) | Article Title | Journal | Volume (Issue) | Pages | Year | Link |
|---|---|---|---|---|---|---|
| Grant, B. D., et al. | SARS-CoV-2 Coronavirus Nucleocapsid Antigen-Detecting Half-Strip Lateral Flow Assay Toward the Development of Point of Care Tests Using Commercially Available Reagents | Anal. Chem. | 92(16) | 11305–11309 | 2020 | View |
| Bradbury, D. W., et al. | On-demand nanozyme signal enhancement at the push of a button for the improved detection of SARS-CoV-2 nucleocapsid protein in serum | Analyst | 146(24) | 7386–7393 | 2021 | View |
| Brunauer, A., et al. | Rapid Detection of Pathogens in Wound Exudate via Nucleic Acid Lateral Flow Immunoassay | Biosensors | 11(3) | 74 | 2021 | View |
| Grant, B. D., et al. | A SARS-CoV-2 coronavirus nucleocapsid protein antigen-detecting lateral flow assay | PLoS ONE | 16(11) | e0258819 | 2021 | View |
| Anderson, C. E., et al. | Automated liquid handling robot for rapid lateral flow assay development | Anal. Bioanal. Chem. | 414(8) | 2607–2618 | 2022 | View |
| Bradbury, D. W., et al. | Combination of the lateral-flow immunoassay with multicolor gold nanorod etching for the semi-quantitative detection of digoxin | Analyst | 147(18) | 4000–4007 | 2022 | View |
| Klebes, A., et al. | Multianalyte lateral flow immunoassay for simultaneous detection of protein-based inflammation biomarkers and pathogen DNA | Sensors and Actuators B: Chemical | 355 | 131283 | 2022 | View |
| Mattila, J.-K., et al. | RapidQ: A reader-free microfluidic platform for the quantitation of antibodies against the SARS-CoV-2 spike protein | Biomicrofluidics | 16(2) | 24105 | 2022 | View |
| Hallerbach, K., et al. | Protein-Based Anchoring Methods for Nucleic Acid Detection in Lateral Flow Format Assays | Micromachines | 14(10) | 1936 | 2023 | View |
| Kim, H., et al. | CRISPR/Cas-Assisted Nanoneedle Sensor for Adenosine Triphosphate Detection in Living Cells | ACS Appl. Mater. Interfaces | 15(43) | 49964–49973 | 2023 | View |
| Ayrton, J.-P., et al. | Multivalent nanobody engineering for enhanced physisorption and functional display on gold nanoparticles | Nanoscale | 16(42) | 19881–19886 | 2024 | View |
| Kang, S.-W., et al. | Cleavage Reaction Lateral Flow Assays for Salivary Pepsin Measurement Using a Pepsin-Susceptible Peptide Substrate | Chemosensors | 12(11) | 241 | 2024 | View |
| Meng, X., et al. | Pitfalls and challenges of peptide nucleic acid immobilisation on carbon surfaces for sequence-specific capturing of nucleic acid biomarkers | Biosens. Bioelectron. | 264 | 116634 | 2024 | View |
| Souza, S. D., et al. | The development of lateral flow devices for urinary biomarkers to assess kidney health | Sci. Rep. | 14(1) | 8516 | 2024 | View |
| Kainz, D. M., et al. | Centrifugal Microfluidic Lateral Flow Assay Enables High Sensitivity Interleukin-6 Detection and Ultrafast Readout of Elevated Analyte Levels | Anal. Chem. | 97(16) | 8984–8991 | 2025 | View |
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Frequently Asked Questions
What is the advantage of using Polystreptavidin R over traditional streptavidin?
Polystreptavidin R offers several advantages over traditional Streptavidin, including higher binding capability due to multiple Streptavidin molecules per polymer unit, reduced background binding due to minimized nonspecific interactions, and enhanced stability in various biological and chemical conditions.
What is the activity of Polystreptavidin R?
Activity is measured by biotin binding capacity. The biotin binding capacity is > 11.0 U/mg, as measured by a HABA assay. Capacity is given as U/mg, defined as 1U = binds 1ug Biotin at pH7.
What is the size of Polystreptavidin R?
The size is between 2,000 and 20,000 kDa, as the polymerised product final purification step is field-flow-fractionation.
Can the large size of Polystreptavadin R be a drawback?
The size of Polystreptavidin R is typically an asset.
The larger three dimensional size increases the amount of biotin that can be bound per assay and has the potential to reduce antibody requirements.
Can Polystreptavidin R be used for applications beyond Lateral Flow?
Yes. Polystreptavidin can be used in a wide variety of applications including ELISA and CLIA methods.
How can Polystreptavidin R be diluted?
Polystreptavidin R is dilutable with Phosphate Buffered Saline (PBS). No specific pH is recommended, however, solutions above pH 8 should be avoided.
What is the shelf life and how should I store it?
The use-by date of Polystreptavadin R is 24 months from the date of manufacture when stored at the appropriate temperature of 2-8°C. Do not freeze.
Can I order in bulk amounts?
Yes. We are happy to supply bulk amounts of our Polystreptavidin R. For larger orders please email our sales team who will be happy to help you take the next steps: info@bbisolutions.com
I achieved great results with my sample, where can I send future orders?
We’re glad to hear it. You can order Polystreptavadin R by emailing our customer service team.
I have more questions about Polystreptavidin R!
Our in-house team of technical experts are happy to support you with any further questions you might have.