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Autoimmune and Inflammation

BBI Solutions Autoimmune and Inflammation Antibodies

At BBI Solutions, we offer a range of monoclonal antibodies to autoimmune and inflammation markers to ensure the reliability and performance of your critical diagnostic assays.

BBI Solutions’ monoclonal antibodies are renowned as sensitive, cost-efficient products for assay developers, manufacturers and researchers worldwide. They are available in both small and bulk quantities depending on your individual needs.

Please contact our Customer Services Team directly to disuss your requirements on tel:+44 (0) 1495 363000 or alternatively you can submit an enquiry here.

Inflammation antibodies

Product description	Product code	Quantity
Ferritin monoclonal antibody	BM210-P3A8	1mg
Procalcitonin Monoclonal Antibody	BM448-H9F1	1mg
Procalcitonin Monoclonal Antibody	BM448-K8C7	1mg
Procalcitonin Monoclonal Antibody	BM448-V4A1	1mg
Rabbit Ferritin Polyclonal Antibody	BP230-3	1mg
CRP Recombinant Fab Monoclonal Antibody	BR228-D4A3
Human Lactoferrin Monoclonal Antibody	MAB232P	1mg
Human Lactoferrin Monoclonal Antibody	MAB233P	1mg
Ferritin Monoclonal Antibody	MAB290P	1mg

Autoimmune Antibodies (humanised)

Uses of Humanised Antibodies in Immunoassays

Immunoassays for the detection of antibodies in patient samples and serological methods require reference materials to determine cut-off values and test assay integrity, and these are then included in the kit as calibrators and positive controls. One of the latest advances in assay development is the use of chimeric antibodies as an alternative to characterised disease state plasma which is limited in availability, shows variability and also has safety and ethical issues. BBI has developed a range of specific chimeric antibodies for these applications where disease state plasma is difficult to source.

Please contact our Customer Services Team directly to discuss your requirements on tel:+44 (0) 1495 363000 or alternatively you can submit an enquiry here.

Disease area	Product code	Product	Quantity
Connective Tissue Diseases	PCNA humAb IgG	36600 36601	0.1 mg 1.0 mg
	Jo-1 humAb IgG	37300 37301	0.1 mg 1.0 mg
	PL-7 humAb IgG	36800 36801	0.1 mg 1.0 mg
	PL-12 humAb IgG	36900 36901	0.1 mg 1.0 mg
	SRP54 humAb IgG	36500 36501	0.1 mg 1.0 mg
	Mi-2 humAb IgG	36700 36701	0.1 mg 1.0 mg
Autoimmune Liver Diseases	LKM1 humAb IgG	36400 36401	0.1 mg 1.0 mg
	LC1 humAb IgG	37100 37101	0.1 mg 1.0 mg
	SLA/LP humAb IgG	36200 36201	0.1 mg 1.0 mg
	PDC-E2 humAb IgG	37200 37201	0.1 mg 1.0 mg
	Sp100 humAb IgG	37000 37001	0.1 mg 1.0 mg

FAQs

Our team are here to help! If you can’t find the answer you are looking for contact us.

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Antibodies are a critical component of the defense arsenal assisting with identifying, capturing, andremoving potential threats as well as protecting against future invasions. Antibodies are
gammaglobulin proteins, predominantly referred to as immunoglobulins (Ig). A monomeric antibody is composed of two heavy chains and two light chains covalently linked together through disulfide
bonds to generate a Y-shaped structure. This Y-shaped structure provides a bifunctional capacity: 1) antigen-binding through the Fab (antigen binding fragment), and 2) interaction with immune cells and
proteins (fragment crystallizable or Fc) to initiate and regulate host defence mechanisms.

Polyclonal antibodies refer to a mixture of immunoglobulin molecules that are secreted against a particular antigen. They interact with different epitopes on the same antigen and their manufacture
does not require the use of hydbridomas.

Monoclonal antibodies refer to a homogenous population of antibodies that are produced by a single clone of plasma B cells. They interact with a particular epitope on the antigen and their
manufacture requires the use of a hybridoma cell line.

This varies between products, please consult the example Certificate of Analysis for this information.

Yes, we manufacture many of our own products at our 2 manufacturing sites in Maine, USA and Porton Down, UK. All sites are ISO13485 certified.

BBI Solutions offers a growing portfolio of performance proven antibodies. With our in-house custom antibody expertise, customers can rely on BBI to be a trusted partner in antibody support, from secure
supply, to matched pair recommendations, and trouble shooting performance. Custom manufacturing lots and conjugation services are also value-added services available for most of our antibodies to suit your assay development needs.

A matched antibody pair consists of two antibodies, a capture and a detection antibody. In a matched pair, each antibody is specific for a different and non-interfering epitope of the antigen.

Hybridoma.

Rabbit, Goat and Sheep.

Roller bottle for lot sizes up to 1gram. Hollow fibre continuous perfusion system for lot sizes greater than 1 gram.

4-6 months for a monoclonal antibody and 3-4 months for a polyclonal.

A discussion with a service team member will be necessary regarding this, however monoclonal development projects start at $20k and up.

High performing Autoimmune and Inflammation Antibodies

At BBI Solutions, we offer a range of monoclonal antibodies to a variety of inflammation markers to ensure the reliability and performance of your critical diagnostic assays.

CRP

Monoclonal antibody for sensitive detection
Multiple applications tested
Total reagent solution with BBI’s own CRP antigen

Procalcitonin

Multiple matched pair options
Excellent sensitivity
Competitive bulk pricing
Total reagent solution with BBI’s own Procalcitonin antigen

Ferritin

Multiple matched pair options including self-pair
Sensitive detection of ferritin
Total reagent solution with BBI’s own Ferritin antigen

Technical Documents

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BBI Solutions Products and Services Brochure

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Autoimmune and Inflammation

BBI Solutions Autoimmune and Inflammation Antibodies

Inflammation antibodies

Autoimmune Antibodies (humanised)

Uses of Humanised Antibodies in Immunoassays