Allergy
Allergy components from BBI
In addition to our Autoimmune products, our scientists have isolated a range of high-quality Allergy components. These components have been developed after assessing the proteome of the target organism for some important food and aeroallergens. They are now used in many In Vitro methods for determination of the specific target for a serological IgE allergic response.
The company objective has been to derive a focused list of targets for allergic conditions where high specification and highly reproducible products are required to give the best performance across different assay platforms including ELISA, microarray and line assay.
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Products & Services
Inside this catalog you’ll find one of the industry’s broadest collections of enzymes, antibodies, antigens, and more – meticulously developed to power world-class diagnostics and keep your pipeline moving.
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Reagents Range
Discover our collection of reagents covering a comprehensive range of biomarkers and applications for the IVD market, life sciences, cell culture and beyond.
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What are antigens and how are they used?
BBI antigens are purified human proteins—either native or recombinant—that serve as critical reagents for making in-vitro-diagnostic (IVD) calibrators and quality-control materials; in some cases they also provide specific biological functionality for research or cell-based assays.
What is the source material for your antigens?
Depending on the product, antigens are produced recombinantly in prokaryotic or eukaryotic systems, purified from consented human tissues or body fluids, or harvested from well-characterised human cell lines.
Where are the antigens manufactured and purified?
Manufacturing takes place at BBI’s ISO 13485-certified facilities in Crumlin, UK, and Freiburg, Germany, both of which operate strict quality-management systems and traceable batch records.
How does BBI guarantee lot-to-lot consistency?
Every production lot follows documented SOPs, is subjected to biochemical and immunological testing, and must meet tight release specifications before it leaves QC, ensuring reproducible performance in your assay.
How should I handle the material when it arrives?
Store at the temperature specified on the CoA.
How can I obtain pricing?
Pricing is volume-dependent; you can check our online shop or request a formal quotation from your account manager or contact customer services.
How do I check stock availability or secure future supply?
Your account manager can provide current inventory levels, arrange reservations, and help integrate your six-month forecasts into our production planning. You can also contact us or use our online shop if you don’t have an account manager yet.
What is the process if I have a complaint or quality concern?
All complaints should be sent to Complaints@bbisolutions.com. All issues are investigated under BBI’s ISO 13485 quality-management system, and we will work with you to reach a satisfactory resolution.
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How are the Allergy components derived?
BBI derives its range of Allergy components either directly by purification from the host organism or by molecular methods where proteins are expressed in specific host organisms. The host cell lines are stored and then propagated in our bioreactor systems.
Some of our recombinant products are expressed with specific His-tag sequences to facilitate purification by nickel chelate affinity chromatography.
The organism derived native and untagged products are purified by a sequential series of different chromatography techniques. The purified proteins are then formulated liquid in the most appropriate stabilising buffer and filtered to 0.2µm to ensure low bioburden.
Products are characterised prior to fill to determine the recovery and purity of the protein using a range of analytical techniques. Techniques such as Coomassie stained SDS-PAGE are used to test and verify the product purity. Importantly, our allergy components for serological applications are tested against a defined panel of patient samples to verify their performance.
Quality assured
After the products have been filled and formulated, they are retested by our independent Quality Control laboratory to verify the analytical results and define the biological integrity. Materials are prepared, stored and shipped from our Freiburg facility, directly supplying clients in Europe and non-China Asia territories. For customers in America and China, our Freiburg products are distributed through our carefully selected and highly reputable partners.
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Why choose purified allergy components from BBI Solutions?
Our range of Allergy components target specific food and aeroallergens. Targets are derived either by isolation from the specific organism or using molecular methods usingin carefully chosen recombinant expression systems. Products are made to order or available from stock using processes defined by specific batch records.
We endeavour to always supply material to our customers’ timelines but rely on our clients to provide forecasts and estimates of usage. Materials are prepared using a range of purification technologies, some of these unique to BBI. Products are extensively characterised and are formulated to optimise shelf-life and we provide material in the most convenient storage format, often stored in ultra-cold systems to ensure maximum shelf-life.
Performance testing
Analytical testing is performed to demonstrate the product purity and recovery using immunological and/or biochemical protein assays. Products are tested with or referenced against specific stored patient samples to ensure the performance.
Food Allergens
| Product Name | Code | Type | Applications | |
|---|---|---|---|---|
| Peanut (Arachis hypogaea) - Ara h 1.0101 | 52501 | Antigens/Proteins | ELISA, Lineblot | Buy now |
| Peanut (Arachis hypogaea) - Ara h 2.0201 | 50101 | Antigens/Proteins | ELISA, Lineblot | Buy now |
| Peanut (Arachis hypogaea) - Ara h 3.0101 | 52601 | Antigens/Proteins | ELISA, Lineblot | Buy now |
| Peanut (Arachis hypogaea) - Ara h 6.0101 | 51901 | Antigens/Proteins | ELISA, Lineblot | Buy now |
| Peanut (Arachis hypogaea) - Ara h 8.0101 | 52701 | Antigens/Proteins | ELISA, Lineblot | Buy now |
| Peanut (Arachis hypogaea) - Ara h 9.0101 | 52001 | Antigens/Proteins | ELISA, Lineblot | Buy now |
| Hazelnut (Corylus avellana) - Cor a 1.0401 | 51801 | Antigens/Proteins | ELISA, Lineblot | Buy now |
| Hazelnut (Corylus avellana) - Cor a 8.0101 | 54201 | Antigens/Proteins | ELISA, Lineblot | Buy now |
| Hazelnut (Corylus avellana) - Cor a 9 (non recombinant) | 54300 | Antigens/Proteins | ELISA, Lineblot | Buy now |
| Hazelnut (Corylus avellana) - Cor a 14.0101 | 54401 | Antigens/Proteins | ELISA, Lineblot | Buy now |
| Soybean (Glycine Max) - Gly m 4.0101 | 50501 | Antigens/Proteins | ELISA, Lineblot | Buy now |
| Soybean (Glycine Max) - Gly m 5.0101 | 50601 | Antigens/Proteins | ELISA, Lineblot | Buy now |
| Apple (Malus domestica) - Mal d 1.0108 | 52801 | Antigens/Proteins | ELISA, Lineblot | Buy now |
| Apple (Malus domestica) - Mal d 3.0101 | 53101 | Antigens/Proteins | ELISA, Lineblot | Buy now |
| Shrimp (Penaeus aztecus) - Pen a 1.0101 | 54101 | Antigens/Proteins | ELISA, Lineblot | Buy now |
| Common Wheat (Triticum aestivum) - Tri a 14.0101 | 54501 | Antigens/Proteins | ELISA, Lineblot | Buy now |
Grass Allergens
| Product Name | Code | Type | Applications | |
|---|---|---|---|---|
| Mugwort (Artemisia vulgaris) - Art v 1.0101 | 51001 | Antigens/Proteins | ELISA, Lineblot | Buy now |
| Timothy (Phleum pratense) - Phl p 1.0102 | 51301 | Antigens/Proteins | ELISA, Lineblot | Buy now |
| Timothy (Phleum pratense) - Phl p 2.0101 | 51400 | Antigens/Proteins | ELISA, Lineblot | Buy now |
| Timothy (Phleum pratense) - Phl p 5.0203 | 51501 | Antigens/Proteins | ELISA, Lineblot | Buy now |
| Timothy (Phleum pratense) - Phl p 6.0101 | 51601 | Antigens/Proteins | ELISA, Lineblot | Buy now |
| Timothy (Phleum pratense) - Phl p 7.0101 | 52301 | Antigens/Proteins | ELISA, Lineblot | Buy now |
| Timothy (Phleum pratense) - Phl p 12.0101 | 52401 | Antigens/Proteins | ELISA, Lineblot | Buy now |
Tree Allergens
| Product Name | Code | Type | Applications | |
|---|---|---|---|---|
| Black Alder (Alnus glutinosa) - Aln g 1.0101 | 50701 | Antigens/Proteins | ELISA, Lineblot | Buy now |
| Black Alder (Alnus glutinosa) - Aln g 4.0101 | 50801 | Antigens/Proteins | ELISA, Lineblot | Buy now |
| Bet v 1.0101 | 50200 | Antigens/Proteins | ELISA, Lineblot | Buy now |
| Bet v 2.0101 | 50301 | Antigens/Proteins | ELISA, Lineblot | Buy now |
| Bet v 4.0101 | 52101 | Antigens/Proteins | ELISA, Lineblot | Buy now |
| Bet v 6.0102 | 52201 | Antigens/Proteins | ELISA, Lineblot | Buy now |
| Car b 1.0109 | 51201 | Antigens/Proteins | ELISA, Lineblot | Buy now |
| Fra e 1.0101 | 50901 | Antigens/Proteins | ELISA, Lineblot | Buy now |
BBI's Capabilities
Specialists
We have extensive experience in sourcing raw materials worldwide
Salt/solvent fractionation
Batch sizes of up to 5,000 litres
Chromatography
Ion exchange chromatography, affinity chromatography, size exclusion chromatography, hydrophobic interaction chromatography
Crystallisation
Highly effective protein purification using solvent and aqueous media
Ultrafiltration
Volumes of 2,500 - 30,000 litres
Freeze drying
Capability of 49 - 420 litres per cycle
Quality control
In-process analysis and monitoring, development of assay/test procedures
Product handling/sampling
We offer special packing according to customer specifications